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Table 2 Surveillance colonoscopies

From: Endoscopic surveillance for colorectal cancer and its precursor lesions in Lynch syndrome; time for some policy shifts?

 

Total (n = 496)

MLH1 (n = 133)

MSH2 (n = 107)

MSH6 (n = 180)

PMS2 (n = 76)

P-value

Lesions detected during surveillance

 Non-advanced adenoma

569 (89%)

167 (87%)

177 (84%)

173 (96%)

50 (94%)

0.001*

 Advanced adenoma

69 (11%)

21 (11%)

29 (14%)

13 (7%)

6 (11%)

0.225

 Colorectal carcinoma

32 (5%)

15 (8%)

14 (7%)

3 (2%)

1 (2%)

0.024*

Location of non-advanced adenoma

     

0.518

 Right-sided

306 (54%)

98 (59%)

87 (49%)

89 (51%)

31 (62%)

 

 Left-sided

194 (34%)

52 (31%)

67 (38%)

62 (36%)

13 (26%)

 

 Right and Left- sided

68 (12%)

17 (10%)

23 (13%)

22 (13%)

6 (12%)

 

Location of advanced adenomas

     

0.089

 Right-sided

38 (55%)

12 (57%)

12 (41%)

9 (69%)

5 (83%)

 

 Left-sided

30 (44%)

9 (43%)

17 (59%)

3 (23%)

1 (17%)

 

 Right and Left- sided

1 (1%)

0 (0%)

0 (0%)

1 (8%)

0

 

Location of CRC

     

0.355

 Right-sided

23 (70%)

12 (80%)

9 (64%)

2 (67%)

0

 

 Left-sided

9 (30%)

3 (20%)

5 (36%)

1 (33%)

1 (100%)

 
  1. Data are median (IQR) and n (%). CRC colorectal cancer. Advanced adenomas are defined as adenomas > 10 mm or with high-grade dysplasia. Non-advanced adenomas are adenomas < 10 mm and without high-grade dysplasia. Lesions are considered right-sided when located proximal of the splenic flexure. Lesions are considered left sided when located distal of the splenic flexure
  2. *Significant with p<0.05