Table 1 Baseline characteristics
MLH1 (n = 133) | MSH2 (n = 107) | MSH6 (n = 180) | PMS2 (n = 76) | P-value | |
|---|---|---|---|---|---|
Sex (male) | 61 (46%) | 50 (47%) | 71 (39%) | 35 (46%) | 0.542 |
Age (years) | 52 (37–63) | 50 (40–62) | 53 (42–66) | 55 (46–68) | 0.036* |
Age LS diagnosis | 34 (26–47) | 35 (27–48) | 41 (33–54) | 48 (39–55) | < 0.001* |
Age first CRC | 46 (12) | 46 (13) | 47 (12) | 45 (13) | 0.963 |
Lesions found during initial colonoscopy | |||||
Non-advanced adenomas | 23 (17%) | 18 (17%) | 39 (22%) | 14 (18%) | 0.698 |
Advanced adenomas | 3 (2%) | 3 (3%) | 6 (3%) | 2 (3%) | 0.980 |
CRC | 22 (17%) | 9 (8%) | 9 (5%) | 5 (7%) | 0.004* |
Total surveillance period (years) | 10 (5–19) | 15 (5–19) | 7 (4–13) | 6 (2–10) | < 0.001* |
Performed colonoscopies | 8 (4–13) | 8 (4–13) | 5 (3–8) | 4 (2–6) | < 0.001* |
Surveillance interval (years) | 1.7 (1.3–2.2) | 1.9 (1.5–2.2) | 2.0 (1.7–2.2) | 2.0 (1.8–2.3) | 0.007* |