Fig. 1

Endoscopic findings and Pedigree chart of Family 1. a-c Endoscopic findings of the proband (II-1). A complete colonoscopy revealed more than 500 adenomatous polyps in the entire large intestine (a) and an additional EGD detected fundic gland polyposis (b) in the stomach and several non-ampullary duodenal adenoma (c). d Pedigree chart of Family 1