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Table 3 Hazard ratios for ovarian cancer according to molybdenum level

From: Blood molybdenum level as a marker of cancer risk on BRCA1 carriers

Variables

Ovarian cases/total

Univariate

HR (95%CI) P

Multivariate*

HR (95%CI) P

Molybdenum level (µg/l)

   

≤ 0.53

0.53–0.69

> 0.69

Total

3/250

6/251

17/253

26/754

1

1.94 (0.49–7.78) 0.35

5.36 (1.51–18.3) 0.007

1

2.34 (0.57–9.64) 0.24

5.55 (1.59–19.4) 0.007

Year of birth

   

≤ 1965

1965.01–1975

1975.01–1985

> 1985

9/95

8/156

8/321

1/182

1

0.50 (0.19–1.30) 0.15

0.25 (0.10–0.64) 0.004

0.06 (0.01–0.50) 0.009

1

1.08 (0.03–38.2) 0.97

0.34 (0.01–15.6) 0.58

0.08 (0.00-5.7) 0.25

Age at blood draw (years)

   

≤ 40

40.01-50

> 50

12/539

5/124

9/91

1

1.81 (0.64–5.13) 0.27

4.70 (1.98–11.2) 0.0004

1

1.57 (0.13–2.42) 0.44

1.21 (0.03–53.8) 0.92

Oral contraceptive use

   

No

Yes

16/359

10/394

1

0.54 (0.25–1.20) 0.13

1

0.92 (0.38–2.24) 0.86

Hormone Replacement Therapy

   

No

Yes

23/601

3/152

1

0.44 (0.13–1.48) 0.19

1

0.35 (0.10–1.20) 0.10

Smoking history

   

Never

Current

Former

11/436

6/170

9/148

1

1.40 (0.52–3.79) 0.51

2.53 (1.05–6.12) 0.04

1

1.38 (0.50–3.80) 0.53

2.40 (0.96–5.97) 0.06

BMI at date of blood draw (kg/m2)

   

≤ 23.0

> 23.0

10/385

15/333

1

1.74 (0.78–3.87 )0.18

1

1.09 (0.44–2.68) 0.55

  1. * adjusted by all the variables listed in the left column