From: Blood molybdenum level as a marker of cancer risk on BRCA1 carriers
Variables | Breast cases/total | Univariate HR (95%CI) P-value | Multivariate* HR (95%CI) P-value |
---|---|---|---|
Molybdenum level (µg/l) | |||
≤ 0.53 0.53–0.70 > 0.70 | 30/317 36/319 48/321 | 1 1.12 (0.69–1.82) 0.65 1.46 (0.92–2.30) 0.11 | 1 1.13 (0.69–1.85) 0.63 1.46 (0.91–2.33) 0.12 |
Year of birth | |||
≤ 1965 1965.01–1975 1975.01–1985 > 1985 | 34/230 25/215 43/330 12/182 | 1 0.81 (0.48–1.35) 0.42 0.95 (0.61–1.50) 0.83 0.56 (0.29–1.08) 0.09 | 1 0.81 (0.31–2.11) 0.67 1.01 (0.28–3.72 )0.98 0.56 (0.14–2.28) 0.41 |
Age at blood draw (years) | |||
≤ 40 40.01-50 > 50 | 59/549 26/208 29/200 | 1 1.12 (0.71–1.78) 0.62 1.24 (0.79–1.94) 0.34 | 1 1.66 (0.65–4.25) 0.29 1.67 (0.45–6.24) 0.45 |
Oophorectomy | |||
No Yes | 27/393 87/564 | 1 0.83 (0.57–1.21) 0.33 | 1 0.61 (0.37-1.00) 0.05 |
Oral contraceptive use | |||
No Yes | 53/485 61/471 | 1 1.17 (0.81–1.69) 0.40 | 1 1.28 (0.86–1.90) 0.23 |
Hormone replacement therapy | |||
No Yes | 83/697 31/259 | 1 0.87 (0.58–1.32) 0.51 | 1 0.86 (0.54–1.35) 0.50 |
Smoking history | |||
Never Current Former | 54/539 33/215 27/203 | 1 1.60 (1.04–2.47) 0.03 1.33 (0.84–2.12) 0.22 | 1 1.62 (1.05–2.51) 0.03 1.31 (0.82–2.10) 0.26 |
BMI at date of blood draw | |||
≤ 23.0 > 23.0 | 57/450 54/470 | 1 0.88 (0.60–1.27) 0.49 | 1 0.85 (0.57–1.27) 0.43 |