Fig. 1

Family trees. (a) Case 1 is corresponding to II-8. The patient’s brother died of pancreatic cancer at the age of 67. Malignant melanoma was not recognized in this family. E: CDKN2A c.150G > T (p.Gln50His). (b) Case 2 is corresponding to II-4. The patient’s father died of pancreatic cancer in his 60s, and his brother died of pancreatic cancer at age 59. The patient had no personal or family history of malignant melanoma. E: CDKN2A c.67G > T (p.Gly23Cys). P: proband