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Table 5 NRG1 variants associated with hereditary thyroid cancer

From: Genetic susceptibility to hereditary non-medullary thyroid cancer

NRG1 variant

Annotation

Odds ratio

P-value

Type of thyroid cancer

population

Reference

rs2439302

Intron variant

1.36

2.0 × 10− 9

NMTC

Icelandic

Gudmundsson et al. (2012) [27]

1.41

2.78 × 10− 5

PTC

Chinese

Wang et al. (2013) [67]

1.27

0.003

PTC

Japanese

Rogounovitch et al. (2015) [63]

1.46

4.0 × 10− 5

PTC

Kazakh

Mussazhanova et al. (2020) [168]

1.59

2.45 × 10− 5

PTC

Ohio

Liyanarachchi et al. (2013) [70]

1.23

9.29 × 10− 4

PTC

Poland

Liyanarachchi et al. (2013) [70]

rs2466076

Intron variant

1.32

1.5 × 10− 17

NMTC

Icelandic

Gudmundsson et al. (2017) [28]

rs6996585

Intron variant

1.43

9.0 × 10− 12

PTC

Korean

Son et al. (2017) [29]

rs12542743

Intron variant

1.39

1.01 × 10− 10

PTC

Korean

Son et al. (2017) [29]

rs2439304

Promoter variant

1.2

0.001

DTC

Europeans, Melanesians and Polynesians

Guibon et al. (2021) [74]